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Anti-DNA Polymerase ζ, N-Terminal antibody produced in rabbit
产品别名
Anti-DNA Polymerase ζ, N-Terminal antibody produced in rabbit
DPOLZ
DPOZ
POLZ
DNA polymerase ζ catalytic subunit
REV3L
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | The REV3L (reversionless 3-like) gene is mapped to human chromosome 6q21. It codes for a ~350 kDa protein DNA polymerase ζ which localizes to mitochondria. Anti-DNA Polymerase ζ antibody detects endogenous levels of total DNA polymerase ζ protein. |
| Immunogen【免疫原】 | The antiserum was produced against synthesized peptide derived from human DNA Polymerase zeta. Immunogen Range: 231-280 |
| Biochem/physiol Actions【生化/生理作用】 | REV3L (reversionless 3-like) is predominantly involved in DNA damage response, induced by ultraviolet radiation and chemical damaging agents such as cisplatin. The encoded protein DNA Polymerase ζ catalyzes the translesion synthesis (TLS) with less stringent and lower processivity. Loss of gene function is embryonically lethal. Upregulation of REV3L results in spontaneous mutations. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen 352 kDa |
| species reactivity | human, mouse |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | ELISA: 1:20000 immunohistochemistry: 1:50-1:100 |
| NCBI accession no.【NCBI登记号】 | O60673 |
| UniProt accession no.【UniProt登记号】 | O60673 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... REV3L(5980) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
