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Anti-EMMPRIN antibody produced in goat
| 产品编号： | 3359920 |
| 规格： | affinity isolated antibody, lyophilized powder |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-EMMPRIN antibody produced in goat
Anti-Extracellular matrix metalloproteinase inducer
Anti-CD147
基本信息
| MDL number | MFCD02262857 |
| NACRES | NA.41 |
| General description【一般描述】 | Extracellular matrix metalloproteinase inducer (EMMPRIN) or cluster of differentiation 147 (CD147) is a protein encoded by the BSG gene in humans. It is also known as Basigin (BSG). It is a widely expressed plasma membrane protein that has been implicated in a variety of physiological and pathological activities. Expression of CD147 is significantly higher in ectopic endometrial tissues in patients with endometriosis compared to normal endometrial tissues. |
| Immunogen【免疫原】 | purified recombinant mouse extracellular matrix metalloproteinase inducer extracellular domain (amino acids 22-209), expressed in NSO cells. |
| Application【应用】 | Anti-EMMPRIN antibody produced in goat is suitable for western blotting at a concentration of 0.1-0.2μg/mL and indirect ELISA at a concentration of 0.5-1.0μg/mL. |
| Biochem/physiol Actions【生化/生理作用】 | CD147 functions as an extracellular matrix metalloproteinase inducer, regulates lymphocyte responsiveness, monocarboxylate transporter expression and spermatogenesis. It interacts with cyclophilin family and acts as a signaling receptor to extracellular cyclophilins A and B. EMMPRIN expression in epithelial ovarian cancers (EOC) is higher than in benign ovarian tumors and normal ovaries. It is associated with the pathogenesis of acute coronary syndrome (ACS) and may act as a biomarker for ACS. EMMPRIN plays important roles in tumor progression and sunitinib resistance in renal cell carcinoma (RCC). It could act as a novel target for the treatment of RCC. |
| Physical form【外形】 | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | goat |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | lyophilized powder |
| species reactivity | mouse |
| technique(s) | indirect ELISA: 0.5-1.0 μg/mL western blot: 0.1-0.2 μg/mL |
| UniProt accession no.【UniProt登记号】 | P18572 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | mouse ... Bsg(12215) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
