Anti-Gigaxonin (N-terminal) antibody produced in rabbit

NA.41

Gigaxonin (GAN) is encoded by the gene mapped to human chromosome 16q23.2. The encoded protein is characterized with an N-terminal BTB (for broad-complex, ramtrack and bric a brac) domain followed by a six kelch repeats, which are predicted to adopt a β-propeller shape.8

Anti-Gigaxonin (N-terminal) antibody produced in rabbit has been used in immunofluorescence and immunoblotting assay.

Gigaxonin (GAN) acts as a key regulator of intermediate filaments (IFs) and the microtubule-associated protein 1B (MAP1B) light chain degradation, which is required for neuronal survival. GAN contributes to neurofilament architecture. Additionally, it also influences the ubiquitination and degradation of some proteins. Mutation in the gene is associated with the development of giant axonal neuropathy.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

rabbit

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

antigen ~70 kDa

rat, mouse, human

~1.5 mg/mL

immunoprecipitation (IP): 15-30 μg using rat brain extracts (S1 fraction)
indirect immunofluorescence: 10-20 μg/mL using HeLa cells expressing human gigaxonin
western blot: 1-2 μg/mL using mouse brain extracts (S1 fraction), and 1.5-3 μg/mL using SH-SY5Y cell lysates
western blot: 1.5-3 μg/mL using SH-SY5Y cell lysates

Q9H2C0

dry ice

−20℃

human ... GAN(8139)
mouse ... Gan(209239)
rat ... Gan(307893)

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