Anti-GOPC antibody produced in rabbit

HPA024018    Human Protein Atlas characterization data

The gene GOPC (Golgi-associated PDZ and coiled-coil motif-containing protein) is mapped to human chromosome 6q22.1. The protein has a single PDZ (PSD-95, Discs-large and ZO-1)-domain, two coiled-coil motifs and two evolutionarily conserved regions, needed for Golgi localization. The protein is also referred to as CAL (CFTR-associated ligand), PIST (PDZ protein interacting specifically with TC10) and FIG (fused in glioblastoma).

Golgi-associated PDZ and coiled-coil motif-containing protein recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

GOPC (Golgi-associated PDZ and coiled-coil motif-containing protein) mainly regulates the intracellular trafficking of receptors. It interacts with β1-adrenergic receptor and mGluR1a (metabotropic glutamate receptor 1A). GOPC retains the receptors in the cell, thereby reducing their expression on the cell surface. It also controls the recycling and degradation of somatostatin receptor and mGluR5a. GOPC also interacts with CRFR1 (corticotropin-releasing hormone receptor 1) and suppresses the anterograde transport of the protein from the endoplasmic reticulum-Golgi to the cell membrane surface. In mouse model, GOPC-ROS (proto-oncogene tyrosine-protein kinase) fusion gene enhances ICC (intrahepatic cholangiocarcinoma) development.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST74788.

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

Prestige Antibodies^® Powered by Atlas Antibodies

buffered aqueous glycerol solution

human

RNAi knockdown
Learn more about Antibody Enhanced Validation

immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:50-1:200

IEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLY

Q9HD26

wet ice

−20℃

human ... GOPC(57120)

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10 - Combustible liquids

WGK 1