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Anti-GRP75 (SQ-15) antibody produced in rabbit

产品编号:3366257
规格:~1 mg/mL, affinity isolated antibody, buffered aqueous solution
包装规格:200 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3366257200 μL4730
产品别名

Anti-GRP75 (SQ-15) antibody produced in rabbit

Anti-Mortalin

Anti-Mitochondrial Hsp70

Anti-Glucose Regulated Protein 75

Anti-Peptide Binding Protein 74

基本信息
MDL number
MFCD00164609
NACRES
NA.41
General description【一般描述】
GRPs are unresponsive to heat stress and are induced by stress related to glucose starvation or defects in glycoprotein processing. GRP75/mortalin has been localized mainly to the endoplasmic reticulum (ER), but also to various cellular compartments including mitochondria and cytoplasmic vesicles.
GRP75 (glucose-regulated protein 75) belongs to a Hsp70 family of the heat shock proteins.
Immunogen【免疫原】
synthetic peptide corresponding to amino acids 665-679 located at the C-terminus of human GRP75. This sequence is identical in mouse GRP75 (mot-1 and mot-2 isoforms) and highly conserved in rat (1 amino acid substitution).
Application【应用】
Anti-GRP75 antibody produced in rabbit has been used in :
  • immunofluorescence
  • immunoblotting
  • immunocytochemistry

Biochem/physiol Actions【生化/生理作用】
GRP75 (glucose-regulated protein 75) is involved in stress responses to intracellular trafficking, antigen processing, and control of cell proliferation, differentiation, and tumorigenesis. It is induced by low levels of ionizing radiation, glucose deprivation, calcium ionophore, and ozone and its levels correlate with muscle activity, mitochondrial activity, and biogenesis.
Heat shock proteins (HSP) are considered to function as molecular chaperones by transiently binding to newly synthesized proteins to facilitate their correct folding and assembly. GRP75 levels are associated with muscle activity, mitochondrial function and biogenesis.
Physical form【外形】
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
200
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
antigen 75 kDa
species reactivity
canine, mouse, human
concentration【浓度】
~1 mg/mL
technique(s)
indirect immunofluorescence: 1-2 μg/mL using HeLa cells
western blot: 0.2-0.4 μg/mL using whole cell extracts of HeLa, MDCK, and NIH3T3 cells
UniProt accession no.【UniProt登记号】
P38646
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
mouse ... Hspa9(15526)
rat ... Hspa9(291671)
产品说明
Target description【目标描述】
GRP75 (SQ-15) encodes a heat-shock cognate protein. This protein plays a role in the control of cell proliferation.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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