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Anti-HDAC6 antibody produced in rabbit
产品别名
Anti-HDAC6 antibody produced in rabbit
Anti-histone deacetylase 6
基本信息
| MDL number | MFCD04040362 |
| NACRES | NA.41 |
| General description【一般描述】 | HDAC6 is a histone deacetylase that associates with polyubiquitinated protein and also functions as a tubulin deacetylase. Additionally, HDAC6 is known to rescue neurodegeneration. It can also function as a mechanistic link between autophagy and ubiquitin-proteasome system during protein degradation. Rabbit Anti-HDAC6 antibody recognizes canine, human, rat, bovine, and mouse HDAC6. |
| Immunogen【免疫原】 | Synthetic peptide directed towards the N terminal region of human HDAC6 |
| Application【应用】 | Rabbit Anti-HDAC6 antibody can be used for western blot applications at 1.0μg/ml. |
| Biochem/physiol Actions【生化/生理作用】 | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. |
| Sequence【序列】 | Synthetic peptide located within the following region: VGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSFPEGPERLHAIKEQ |
| Physical form【外形】 | Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| species reactivity | rabbit, human, pig, dog, horse |
| concentration【浓度】 | 0.5 mg - 1 mg/mL |
| technique(s) | ChIP: suitable immunohistochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_006035 |
| UniProt accession no.【UniProt登记号】 | Q9UBN7 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... HDAC6(10013) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
