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Anti-IGF-1 antibody produced in goat
产品编号: | 3369301 |
规格: | affinity isolated antibody, lyophilized powder |
包装规格: | 250 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Anti-IGF-1 antibody produced in goat
Anti-Insulin-like Growth Factor-I
基本信息
MDL number | MFCD00162566 |
NACRES | NA.41 |
General description【一般描述】 | Insulin-like growth factor-I (IGF-I) is encoded by the gene mapped to human chromosome 12q23.2. IGF-I belongs to insulin-like growth factor (IGF) family. The encoded protein is ubiquitously expressed, but the circulating form of the protein is mainly found in liver and pancreas. |
Immunogen【免疫原】 | purified, E. coli-derived recombinant human insulin-like growth factor-I. |
Application【应用】 | Anti- IGF-1 antibody may be used for neutralization reactions, the ND50 of the antibody is 3-12 μg/ml. For immunoblotting a working antibody concentration of 0.1-0.2 μg/ml. The recommended antibody concentration for immunocytochemistry is 5-15 μg/ml. The antibody is suitable for immunohistochemistry of formalin-fixed, paraffin-embedded sections. |
Biochem/physiol Actions【生化/生理作用】 | Insulin-like growth factors -1 and -2 are important regulators of signalling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades. The effect of IGF-1 is by endocrine, paracrine and autocrine signalling. The effects of IGF-1 signalling are important at many developmental levels from cells to organ to organism, growth, differentiation, anti-apoptosis, proliferation and transformation. Irregular IGF-1 signaling has been implicated in many cancers including melanoma, breast, lung, colon and prostate. Anti-IGF-I recognizes human insulin-like growth factor I. |
Physical form【外形】 | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose. |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | goat |
conjugate【偶联物】 | unconjugated |
antibody form【抗体形式】 | affinity isolated antibody |
antibody product type | primary antibodies |
form【形式】 | lyophilized powder |
species reactivity | human |
technique(s) | immunocytochemistry: 5-15 μg/mL immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable western blot: 0.1-0.2 μg/mL |
application(s) | research pathology |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... IGF1(3479) |
产品说明
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
WGK | WGK 1 |