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抗-胰岛素样生长因子-I 山羊抗
Anti-Insulin-Like Growth Factor-I antibody produced in goat
产品别名
抗-胰岛素样生长因子-I 山羊抗
Anti-Insulin-Like Growth Factor-I antibody produced in goat
Anti-IGF-I
基本信息
MDL number | MFCD00162566 |
General description【一般描述】 | Insulin-like growth factors -1 and -2 are important regulators of signalling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades. The effect of IGF-1 is by endocrine, paracrine and autocrine signalling. The effects of IGF-1 signalling are important at many developmental levels from cells to organ to organism, growth, differentiation, anti-apoptosis, proliferation and transformation. Irregular IGF-1 signaling has been implicated in many cancers including melanoma, breast, lung, colon and prostate Anti-IGF-I recognizes human insulin-like growth factor I. The antibody does not react with human IGF-II. |
Specificity【特异性】 | The antibody neutralizes the biological activity of recombinant human IGF-I. |
Immunogen【免疫原】 | recombinant human IGF-I expressed in Escherichia coli |
Application【应用】 | Anti- IGF-1 antibody may be used for neutralization reactions, the ND50 of the antibody is 3-12 μg/ml. For immunoblotting a working antibody concentration of 0.1-0.2 μg/ml. |
Physical form【外形】 | Lyophilized from a 0.2 μm filtered solution of phosphate buffered saline, pH 7.4, with 5% trehalose. |
Preparation Note【制备说明】 | Affinity isolated by IGF-I affinity chromatography. |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | goat |
conjugate【偶联物】 | unconjugated |
antibody form【抗体形式】 | affinity isolated antibody |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
form【形式】 | lyophilized powder |
species reactivity | human |
technique(s) | neutralization: 3-12 μg/mL western blot: 0.1-0.2 μg/mL |
UniProt accession no.【UniProt登记号】 | P05019 |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... IGF1(3479) |
产品说明
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 2 |
Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |