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抗-胰岛素样生长因子-I 山羊抗

Anti-Insulin-Like Growth Factor-I antibody produced in goat
产品编号:3370044
规格:affinity isolated antibody
包装规格:250 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3370044250 μG5000
产品别名

抗-胰岛素样生长因子-I 山羊抗

Anti-Insulin-Like Growth Factor-I antibody produced in goat

Anti-IGF-I

基本信息
MDL number
MFCD00162566
General description【一般描述】
Insulin-like growth factors -1 and -2 are important regulators of signalling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades. The effect of IGF-1 is by endocrine, paracrine and autocrine signalling. The effects of IGF-1 signalling are important at many developmental levels from cells to organ to organism, growth, differentiation, anti-apoptosis, proliferation and transformation. Irregular IGF-1 signaling has been implicated in many cancers including melanoma, breast, lung, colon and prostate
Anti-IGF-I recognizes human insulin-like growth factor I. The antibody does not react with human IGF-II.
Specificity【特异性】
The antibody neutralizes the biological activity of recombinant human IGF-I.
Immunogen【免疫原】
recombinant human IGF-I expressed in Escherichia coli
Application【应用】
Anti- IGF-1 antibody may be used for neutralization reactions, the ND50 of the antibody is 3-12 μg/ml. For immunoblotting a working antibody concentration of 0.1-0.2 μg/ml.
Physical form【外形】
Lyophilized from a 0.2 μm filtered solution of phosphate buffered saline, pH 7.4, with 5% trehalose.
Preparation Note【制备说明】
Affinity isolated by IGF-I affinity chromatography.
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
goat
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
lyophilized powder
species reactivity
human
technique(s)
neutralization: 3-12 μg/mL
western blot: 0.1-0.2 μg/mL
UniProt accession no.【UniProt登记号】
P05019
storage temp.【储存温度】
−20℃
Gene Information
human ... IGF1(3479)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 2
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, type N95 (US)
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