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Anti-Interleukin-7 Receptor α/CD127 antibody produced in goat
| 产品编号： | 3370126 |
| 规格： | affinity isolated antibody, lyophilized powder |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Interleukin-7 Receptor α/CD127 antibody produced in goat
Anti-CDW127
Anti-IL7R
Anti-CD127
Anti-ILRA
基本信息
| MDL number | MFCD01864808 |
| General description【一般描述】 | Interleukin-7 (IL-7) is a stromal-cell derived cytokine that is important in the development of adaptive immunity and maintenance of T cells and B cells. The cognate receptor that binds IL-7 is the IL-7 receptor complex, made up of IL-7 R α chain and a γ chain. The expression of IL-7 R is restricted to immature B cells, mature T cells and thymocytes. The binding of IL-7 to its receptor triggers a variety of tightly regulated signalling pathways that are critical for cell survival, proliferation, differentiation and uptake of glucose. The signalling pathways that participate in mediating the effects of IL-7 R are JAK/STAT and PI3K. Additionally the effect of IL-7 on cell cycle is due to the modulation of proteins p27kip1 and Cdc25A. Reports implicate IL-7 R in glucose metabolism and cell size as it modulates the effects of GLUT4 Anti-interleukin-7 receptor α/CD127 recognizes human interleukin-7. |
| Immunogen【免疫原】 | purified, NSO cell-derived recombinant human interleukin-7 soluble receptor α. |
| Application【应用】 | Anti-interleukin-7 receptor α/CD127 antibody may be used for immunoblotting at a working concentration of 0.1-0.2 μg/ml. For flow cytometry, the recommended concentration is 5-10 μg/ml. |
| Physical form【外形】 | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | goat |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | lyophilized powder |
| species reactivity | human |
| technique(s) | flow cytometry: 5.0-10.0 μg/mL western blot: 0.1-0.2 μg/mL |
| UniProt accession no.【UniProt登记号】 | P16871 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... IL7R(3575) |
产品说明
| Target description【目标描述】 | Interleukin-7 Receptor α/CD127 encodes a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 1 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
