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Anti-ITGB3 (Ab-773) antibody produced in rabbit
产品别名
Anti-ITGB3 (Ab-773) antibody produced in rabbit
Anti-GP3A antibody produced in rabbit
Anti-GPIIIa antibody produced in rabbit
Anti-CD61 antibody produced in rabbit
Anti-integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) antibody produced in rabbit
基本信息
| MDL number | MFCD00211790 |
| NACRES | NA.41 |
| General description【一般描述】 | ITGB3 (integrin subunit |
| Immunogen【免疫原】 | Peptide sequence around aa. 771-775 (P-L-Y-K-E), according to the protein ITGB3. |
| Biochem/physiol Actions【生化/生理作用】 | Mutations in ITGB3 (integrin subunit β3) results in Glanzmann thrombasthenia (GT). It plays a major role in the movement and attack of colorectal cancer cells, promoted by reactive oxygen species. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~110 kDa |
| species reactivity | rat, human, mouse |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 western blot: 1:500-1:1000 |
| isotype【同位素/亚型】 | IgG |
| immunogen sequence【免疫原序列】 | (P-L-Y-K-E) |
| NCBI accession no.【NCBI登记号】 | NP_000203.2 |
| UniProt accession no.【UniProt登记号】 | P05106 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... ITGB3(3690) |
产品说明
| Target description【目标描述】 | Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
