Anti-MAPT (Ab-214) antibody produced in rabbit

NA.41

MAPT (microtubule associated protein tau) is located on human chromosome 17q21.3. It is upregulated in neurons but is most prominent in axons.

Peptide sequence around aa. 212-216 (T-P-S-L-P), according to the protein MAPT.

Removal of MAPT results in developmental delay and learning disability. It participates in the pathology of Alzheimer′s disease (AD). It helps in the assembly and maintenance of microtubule structure.

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Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

~48 kDa
~62 kDa
~78 kDa

human, mouse, rat

1 mg/mL

indirect immunofluorescence: 1:100-1:200

IgG

(T-P-S-L-P)

NP_001116538.1

P10636

wet ice

−20℃

human ... MAPT(4137)

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

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12 - Non Combustible Liquids

WGK 1