您的位置：首页 > 产品中心 > Anti-MELK antibody produced in rabbit
Anti-MELK antibody produced in rabbit
产品别名
Anti-MELK antibody produced in rabbit
Anti-hMELK
Anti-KIAA0175
Anti-HPK38
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Maternal embryonic leucine zipper kinase (MELK) is a serine/threonine kinase that exists in bi-lobal conformation. Structurally, MELK comprises an N-terminal catalytic domain, ubiquitin-associated (UBA) domain, and a kinase domain. The MELK gene is mapped to human chromosome location 9p13.2.The MELK antibody detects endogenous levels of total MELK protein. |
| Immunogen【免疫原】 | Peptide sequence around aa. 626-630 (I-R-R-Q-R), according to the protein NP_055606.1 |
| Application【应用】 | Anti-MELK antibody produced in rabbit has been used in western blotting at a dilution of 1:1000. |
| Biochem/physiol Actions【生化/生理作用】 | Maternal embryonic leucine zipper kinase (MELK) participates in cell cycle regulation by interacting with cell cycle proteins. It may have a role in malignant cell survival and cancer stem cell growth. An elevated expression of MELK is observed in triple-negative breast cancer, glioblastoma multiforme(GBM), and astrocytomas. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~74 kDa |
| species reactivity | human, rat, mouse |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | western blot: 1:500-1:1000 |
| isotype【同位素/亚型】 | IgG |
| immunogen sequence【免疫原序列】 | (I-R-R-Q-R) |
| NCBI accession no.【NCBI登记号】 | NM_014791.2 |
| UniProt accession no.【UniProt登记号】 | Q14680 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... MELK(9833) |
产品说明
| Target description【目标描述】 | Phosphorylates ZNF622 and may contribute to its redirection to the nucleus. May be involved in the inhibition of spliceosome assembly during mitosis. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
