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Anti-MR-Pro ADM antibody produced in rabbit

产品编号:3377906
包装规格:100 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3377906100 μL6090
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
200
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
form【形式】
buffered aqueous solution
mol wt【分子量】
antigen ~5 kDa
species reactivity
human
concentration【浓度】
~1 mg/mL
technique(s)
immunoblotting: 0.25-0.5 g/mL
immunofluorescence: 2.5-5 μg/mL
immunohistochemistry: 10-20 μg/mL
UniProt accession no.【UniProt登记号】
P35318
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... ADM(133)
基本信息
General description【一般描述】
MR-pro-ADM (mid-regional-pro-adrenomedullin) is a 47-residue long peptide, produced during posttranslational processing of adrenomedullin. It has a molecular weight of 5.1kDa. Adrenomedullin (ADM) is a vasodilator peptide, which is produced and released by a wide variety of cells such as, macrophages, fibroblasts, cardiomyocytes etc. MR-pro-ADM functions as a substitute marker for ADM. This peptide is coded by the gene localized to human chromosome 11p15.4, which is composed of four exons and three introns.
Immunogen【免疫原】
a synthetic peptide corresponding to the internal region of human Adrenomedullin (ADM) , conjugated to KLH.
Biochem/physiol Actions【生化/生理作用】
In hemodialysis patients increased plasma levels of MR-pro-ADM (mid-regional-pro-adrenomedullin) is linked with decreased survival. This is due to increased vasodilation in response to higher levels of MR-pro-ADM; lower levels of this peptide result in increased vasoconstriction and hence, better prognosis. This peptide is also associated with increased cardiovascular mortality in dialysis patients. In type II diabetic patients, MR-pro-ADM peptide is linked with renal outcome, as adrenomedullin (ADM) gene regulates susceptibility to nephropathic progression.
Physical form【外形】
Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
nwg
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