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Anti-MR-Pro ADM antibody, Mouse monoclonal

产品编号:3377908
规格:clone MR2.1, purified from hybridoma cell culture
包装规格:100 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3377908100 μL6730
产品别名

Anti-MR-Pro ADM antibody, Mouse monoclonal

Midregional proadrenomedullin

基本信息
NACRES
NA.41
General description【一般描述】
Anti-MR-Pro ADM antibody, Mouse monoclonal (MidRegional pro-Adrenomedullin) (mouse IgG2a isotype) is derived from the hybridoma MR2.1 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to the internal region of human Adrenomedullin (ADM), conjugated to KLH. The precursor peptide of Adrenomedullin (ADM), prepro-ADM, is processed to the circulating form of ADM. During this processing, other peptides are also being generated; PAMP (proadrenomedullin N-terminal 20 peptide) with suggested hypotensive effect, and MR-pro ADM (Mid-Regional pro-Adrenomedullin) which consists of 47 amino acid-propeptide.
Immunogen【免疫原】
Synthetic peptide corresponding to the internal region of human Adrenomedullin (ADM), conjugated to KLH.
Application【应用】
Anti-MR-Pro ADM antibody has been used in immunoblotting, immunohistochemistry.
Biochem/physiol Actions【生化/生理作用】
MR-pro ADM (MidRegional pro-Adrenomedullin) has been suggested as a biomarker for plasma concentrations of Adrenomedullin as it is stoichiometrically generated and relatively stable in the plasma. Increased levels of MR-pro ADM were associated with an increased risk of mortality and morbidity in patients with heart failure, independent of natriuretic peptides. In dialysis patients MR-pro ADM and MR-pro ANP were shown to be associated with mortality in general and particularly with cardiovascular related mortality, with the highest risk when both parameters were elevated.
Physical form【外形】
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide
Legal Information【法律信息】
ExtrAvidin is a registered trademark of sigma-aldrich Co. LLC
产品性质
Quality Level【质量水平】
200
biological source【生物来源】
mouse
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
MR2.1, monoclonal
form【形式】
buffered aqueous solution
species reactivity
human
concentration【浓度】
~1 mg/mL
technique(s)
immunoblotting: 1-2 μg/mL using human recombinant peptide of MR-Pro ADM (amino acid 45-92)
immunohistochemistry: 2.5-5 μg/mL using Biotin/ExtrAvidin®-Peroxidase staining system of heat-retrieved formalin-fixed, paraffin-embedded human Pancreas sections
isotype【同位素/亚型】
IgG2a
UniProt accession no.【UniProt登记号】
P35318
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... ADM(133)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
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