Anti-MR-Pro ADM antibody, Mouse monoclonal

NA.41

Anti-MR-Pro ADM antibody, Mouse monoclonal (MidRegional pro-Adrenomedullin) (mouse IgG2a isotype) is derived from the hybridoma MR2.1 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to the internal region of human Adrenomedullin (ADM), conjugated to KLH. The precursor peptide of Adrenomedullin (ADM), prepro-ADM, is processed to the circulating form of ADM. During this processing, other peptides are also being generated; PAMP (proadrenomedullin N-terminal 20 peptide) with suggested hypotensive effect, and MR-pro ADM (Mid-Regional pro-Adrenomedullin) which consists of 47 amino acid-propeptide.

Synthetic peptide corresponding to the internal region of human Adrenomedullin (ADM), conjugated to KLH.

Anti-MR-Pro ADM antibody has been used in immunoblotting, immunohistochemistry.

MR-pro ADM (MidRegional pro-Adrenomedullin) has been suggested as a biomarker for plasma concentrations of Adrenomedullin as it is stoichiometrically generated and relatively stable in the plasma. Increased levels of MR-pro ADM were associated with an increased risk of mortality and morbidity in patients with heart failure, independent of natriuretic peptides. In dialysis patients MR-pro ADM and MR-pro ANP were shown to be associated with mortality in general and particularly with cardiovascular related mortality, with the highest risk when both parameters were elevated.

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide

ExtrAvidin is a registered trademark of sigma-aldrich Co. LLC

200

mouse

unconjugated

purified immunoglobulin

primary antibodies

MR2.1, monoclonal

buffered aqueous solution

human

~1 mg/mL

immunoblotting: 1-2 μg/mL using human recombinant peptide of MR-Pro ADM (amino acid 45-92)
immunohistochemistry: 2.5-5 μg/mL using Biotin/ExtrAvidin^®-Peroxidase staining system of heat-retrieved formalin-fixed, paraffin-embedded human Pancreas sections

IgG2a

P35318

dry ice

−20℃

human ... ADM(133)

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12 - Non Combustible Liquids