Anti-MTMR6 (C-term) antibody produced in rabbit

NA.41

The myotubularin (MTM) family constitutes one of the largest and most highly conserved protein-tyrosine phosphatase (PTP) subfamilies. Myotubularins, contain the consensus active site of tyrosine phosphatases but otherwise shows no homology to other phosphatases. PTP′s usually act on substrates containing only phosphotyrosine sites, but myotubularins were shown to act on both phosphotyrosine and phosphoserine (dual specific). The enzymatic activity of myotubularins had not been demonstrated previously because it lacks catalytically active residues in tyrosine phosphatase/dual-specific phosphatase active site. The active site is however sufficiently preserved to bind phosphorylated substrates, and may protect from phosphatases. It was reported that interaction of myotubularin family members makes one of them catalytically active. The 4.8-kb MTMR6 mRNA is expressed ubiquitously. By analysis of radiation and somatic cell hybrids, the MTMR6 gene has been mapped to 13q12. MTMR6 corresponds to an EST located within a cloned region that encompasses a translocation breakpoint t(8;13) observed in 2 patients with an atypical myoproliferative disorder.

MTMR6 (Q9Y217, 582-617)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human MTMR6.

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

rabbit

100

unconjugated

IgG fraction of antiserum

primary antibodies

polyclonal

buffered aqueous solution

human, mouse

immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000
western blot: 1:100-1:500

NP_004676

Q9Y217

dry ice

−20℃

human ... MTMR6(9107)

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12 - Non Combustible Liquids

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