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Anti-Mucolipin-2 (C-terminal) 兔抗
Anti-Mucolipin-2 (C-terminal) antibody produced in rabbit
| 产品编号： | 3378742 |
| 规格： | ~1 mg/mL, affinity isolated antibody, buffered aqueous solution |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Mucolipin-2 (C-terminal) 兔抗
Anti-Mucolipin-2 (C-terminal) antibody produced in rabbit
Anti-MLN2
Anti-MCOLN2
Anti-TRPML2
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Mucolipin-2 (MLN2) is a member of transient receptor potential (TRP) protein superfamily. It consists of gated, tetrameric cation channels. MLN2 has a conserved structure of six transmembrane helices with differing cytoplasmic oriented N- and C-terminal domains. It is localized to late endosomes and lysosomes.. |
| Specificity【特异性】 | Additional bands may be observed at ~120 kDa and ~35 kDa due to aggregation and degradation, respectively. |
| Immunogen【免疫原】 | synthetic peptide corresponding to amino acids 534-549 of human mucolipin-2. This sequence has low homology with rat (73% identity) and mouse (66% homology) mucolipin-2. |
| Application【应用】 | Anti-Mucolipin-2 (C-terminal) antibody produced in rabbit has been used in immunoblotting. |
| Biochem/physiol Actions【生化/生理作用】 | Mucolipin-2 (MLN2) plays an important role in lysosome maturation, lysosome fission, late endosome-lysosome fusion, autophagosome-lysosome fusion, lysosome expulsion and iron release. It stimulates autophagy proliferation via transcription factor EB (TFEB) activation. MLN2 is involved in B‐lymphocyte development. |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~60 kDa |
| species reactivity | human |
| packaging【包装】 | antibody small pack of 25 μL |
| enhanced validation【增强验证】 | recombinant expression Learn more about Antibody Enhanced Validation |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | western blot: 0.3-0.6 μg/mL using HEK-293T cells expressing human mucolipin-2 |
| UniProt accession no.【UniProt登记号】 | Q8IZK6 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... MCOLN2(255231) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
