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Anti-OCT3 antibody produced in rabbit

产品编号:3380853
规格:affinity isolated antibody
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3380853100 μG5040
产品别名

Anti-OCT3 antibody produced in rabbit

OCT4

OCT3

OCTAMER-BINDING TRANSCRIPTION FACTOR 3

OTF3

OTF4

基本信息
MDL number
MFCD02263853
NACRES
NA.41
General description【一般描述】
Octamer-binding transcription factor 3 (OCT3)/OCT4 is encoded by the gene spanning 1420 bases of genomic DNA mapped to human chromosome 6p21.33. OCT3/OCT4 is a transcription factor that belongs to the transcription Pit-Oct-Unc (POU)family. This protein contains a POU-specific homeodomain and DNA-binding domain. Anti-OCT3 antibody detects endogenous levels of total OCT3 protein.
Anti-OCT3 Antibody detects endogenous levels of total OCT3 protein.
Immunogen【免疫原】
The antiserum was produced against synthesized peptide derived from human OCT3.

Immunogen Range: 191-240
Application【应用】
Anti-OCT3 antibody produced in rabbit may be used in immunohistochemistry at 1:100 dilution and immunoblot at 1:1000 dilution.
Biochem/physiol Actions【生化/生理作用】
Octamer-binding transcription factor 3 (OCT3)/OCT4 plays a vital role in the self-renewal and pluripotency of embryonic stem cells. It is involved in the regulation of embryonic development and cell fate determination. Overexpression of OCT4 gene aids in the progression of various types of human cancers by increasing tumorigenicity and enhancing resistance to chemotherapeutics. OCT4 expression acts as a potential cancer diagnosis and prognosis biomarker. Reduced expression of the OCT4 gene suppresses the growth of pancreatic cancer cells by blocking the AKT pathway. Therefore, OCT4 protein may be used as an effective therapeutic target for pancreatic cancer treatment.
Features and Benefits【特点和优势】
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form【外形】
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
antigen 38 kDa
species reactivity
mouse, rat, human
concentration【浓度】
~1 mg/mL
technique(s)
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.【NCBI登记号】
Q01860
UniProt accession no.【UniProt登记号】
Q01860
application(s)
research pathology
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... POU5F1(5460)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
nwg
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