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Anti-PDCD4 antibody produced in rabbit

产品编号:3383055
规格:~1 mg/mL, affinity isolated antibody, buffered aqueous solution
包装规格:200 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3383055200 μL6290
产品别名

Anti-PDCD4 antibody produced in rabbit

Anti-Nuclear antigen H731

Anti-Programmed cell death 4

Anti-Neoplastic transformation inhibitor

Anti-Protein 197/15a

基本信息
NACRES
NA.41
General description【一般描述】
Programmed Cell Death 4 (PDCD4 ) is present in the nucleus. PDCD4 gene is mapped to human chromosome 10q25.2. PDCD4 protein consists of two basic domains at the N-terminus and C-terminus and two conserved α-helical MA-3 domains.
Specificity【特异性】
Anti-PDCD4 specifically recognizes human, mouse, and rat PDCD4.
Application【应用】
Anti-PDCD4 antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.
Biochem/physiol Actions【生化/生理作用】
Programmed Cell Death 4 (PDCD4) is a neoplastic transformation inhibitor protein that functions as a tumor suppressor in ovarian carcinoma. The levels of PDCD4 are depleted in progressed carcinomas of the lung, breast, colon, and prostate. MA-3 domain of PDCD4 aids protein-protein interactions in eukaryotic translation initiation factor 4GI(eIF4GI) and eIF4GII with the ATP-dependent RNA helicase eIF4A. PDCD4 suppresses translation initiation by specifically inhibiting the helicase activity of eukaryotic translation initiation factor 4A (eIF4A), a component of the translation initiation complex. In response to mitogens, PDCD4 is rapidly phosphorylated on Ser67 by the protein kinase ribosomal protein S6 kinase 1 (S6K1), and subsequently degraded via the ubiquitin ligase skp, cullin, f-box containing complex beta-transducin repeat-containing protein ((SCF)βTRCP ). It also shows that the protein is specifically phosphorylated on Ser76 and Ser457 by p90 ribosomal S6 kinase (RSK).
Physical form【外形】
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
200
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
antigen ~51 kDa
species reactivity
rat (predicted), mouse (predicted), human
concentration【浓度】
~1 mg/mL
technique(s)
immunoprecipitation (IP): 5-10 μg using HEK-293T cell lysates
western blot: 2-4 μg/mL using K562 cell lysates
UniProt accession no.【UniProt登记号】
Q53EL6
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... PDCD4(272250)
mouse ... Pdcd4(18569)
rat ... SELP(6403)
产品说明
Storage and Stability【储存及稳定性】
For continuous use, store at 2–8 ℃ for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 2
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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