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Anti-PGRMC1 antibody produced in rabbit

产品编号:3383812
规格:affinity isolated antibody
包装规格:100 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3383812100 μL6300
产品别名

Anti-PGRMC1 antibody produced in rabbit

Anti-Progesterone receptor membrane component 1

Anti-HPR6.6

Anti-Mpr

基本信息
MDL number
MFCD02265405
Immunogen【免疫原】
Synthetic peptide directed towards the N terminal region of human PGRMC1
Biochem/physiol Actions【生化/生理作用】
Membrane-associated progesterone receptor component 1 (UniProt: O00264; also known as mPR, PGRMC1) is encoded by the PGRMC1 (also known as HPR6.6, PGRMC) gene (Gene ID: 10857) in human. PGRMC1 is a single pass homodimeric membrane protein that is widely expressed with highest expression observed in liver and kidney. It is also shown to be overexpressed in multiple types of cancers and can serve as an important biomarker of their proliferative state. It has short N-terminal extracellular domain (aa 1-24), a transmembrane domain (aa 25-43), and a cytoplasmic domain (aa 44-195). PGRMC1 is a component of a progesterone-binding protein complex with many cellular functions. It is required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. It also serves as an intracellular heme chaperone that regulates heme synthesis and acts as a heme donor for some hemoproteins. PGRMC1 contains a cytochrome b5 heme-binding domain (aa 72-171) that lacks the conserved iron-binding histidine residue at positions 107 and 131. PGRMC1 is reported to suppress p53 and Wnt/β-catenin pathway to promote self-renewal of pluripotent stem cells (PSCs) and inhibit their differentiation. Its levels are rapidly down regulated during early differentiation of PSCs. (Ref.: Kim, JY et al. (2018). Sci. Rep. 3; 3048; Kim, JY., et al. (2019). Sci. Rep. 9; 653).
Sequence【序列】
Synthetic peptide located within the following region: MAAEDVVATGADPSDLESGGLLHEIFTSPLNLLLLGLCIFLLYKIVRGDQ
Physical form【外形】
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
22 kDa
species reactivity
human
concentration【浓度】
0.5 mg - 1 mg/mL
technique(s)
immunohistochemistry: suitable
western blot: 1 μg/mL
UniProt accession no.【UniProt登记号】
O00264
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... PGRMC1(10857)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 3
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