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Anti-phospho-APP (pThr668) antibody produced in rabbit
| 产品编号： | 3384102 |
| 规格： | affinity isolated antibody, aqueous glycerol solution, 10 blots |
| 包装规格： | 1 VIAL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| MDL number | MFCD06798482 |
| General description【一般描述】 | Amyloid precursor proteins (APPs) are transmembrane glycoproteins that are found in a wide range of tissues. APPs have 3 main isoforms, namely, APP695, APP751 and APP770 that are derived from alternative splicing events in cells. Accumulation of the cleavage products of APP, such as the β-amyloid peptide, can cause Alzheimer′s disease. Rabbit Anti-phospho-APP (pThr668) antibody binds to human APP phosphorylated at Thr668. Mouse, rat and frog APP are 100% homologous. |
| Immunogen【免疫原】 | synthetic phosphopeptide corresponding to the region of APP containing threonine 688. |
| Application【应用】 | Cultured cortical neurons were immunostained for APP using rabbit anti-phospho-APP (pThr688) antibody. Rabbit Anti-phospho-APP (pThr668) antibody can be used for western blot applications at a dilution of 1:1,000. |
| Physical form【外形】 | Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 50% glycerol, 1.0 mg/mL BSA (IgG and protease free) and 0.05% sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | aqueous glycerol solution |
| usage【用途】 | 10 blots |
| mol wt【分子量】 | antigen 100-140 kDa |
| species reactivity | human |
| technique(s) | western blot: 1:1000 using CAD cells transfected with wild type vs. T668A mutant APP. |
| UniProt accession no.【UniProt登记号】 | P05067 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... APP(351) mouse ... App(11820) rat ... App(54226) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
