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Anti-phospho-CFL1 (pSer3) antibody produced in rabbit
产品别名
Anti-phospho-CFL1 (pSer3) antibody produced in rabbit
Anti-CFL antibody produced in rabbit
Anti-cofilin 1 (non-muscle) antibody produced in rabbit
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | The cofilin 1 (CFL1) gene is mapped to human chromosome 11q13.1. It has four exons. The CFL1 gene codes for a ubiquitously expressed, 18.5 kDa phosphoprotein. |
| Immunogen【免疫原】 | Peptide sequence around phosphorylation site of serine 3 (M-A-S(p)-G-V), according to the protein CFL1. |
| Application【应用】 | Anti-phospho-CFL1 (pSer3) antibody produced in rabbit is used in Western Blotting. |
| Biochem/physiol Actions【生化/生理作用】 | Cofilin-l (CFL1) plays a vital role in the regulation of actin cytoskeleton reorganization. It facilitates cytokinesis, cell motility and morphogenesis. CFL1 is also implicated in cancer cell migration and invasion in several types of tumor tissues. Elevated expression of the protein is associated with the development of esophageal squamous cell carcinoma (ESCC). In addition, its abnormal expression leads to vulvar cancer and thus, it can be considered as a potential therapeutic target for the same. Activated CFL1 helps in preventing cytoskeletal-associated defects in axonal development stimulated by synucleins (Syns). |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~19 kDa |
| species reactivity | human, rat, mouse |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 indirect immunofluorescence: 1:100-1:200 western blot: 1:500-1:1000 |
| isotype【同位素/亚型】 | IgG |
| immunogen sequence【免疫原序列】 | (M-A-SP-G-V) |
| NCBI accession no.【NCBI登记号】 | NP_005498.1 |
| UniProt accession no.【UniProt登记号】 | P23528 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... CFL1(1072) |
产品说明
| Target description【目标描述】 | Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
