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Anti-phospho-FAK (pTyr861) antibody produced in rabbit
| 产品编号： | 3384654 |
| 规格： | affinity isolated antibody, buffered aqueous glycerol solution |
| 包装规格： | 1 VIAL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-phospho-FAK (pTyr861) antibody produced in rabbit
Anti-phospho-Focal Adhesion Kinase
基本信息
| MDL number | MFCD03455741 |
| NACRES | NA.44 |
| General description【一般描述】 | Focal adhesion kinase (FAK) is a cytoplasmic protein that belongs to non-receptor protein tyrosine kinase family. It has a critical role in regulation of cell differentiation, migration, adhesion and acceleration of the G1 to S phase transition in cell cycle. Anti-phospho-FAK (pTyr861) antibody can be used in immunohistochemistry. Rabbit anti-phospho-FAK (pTyr861) antibody reacts specifically with FAK (125kD) phosphorylated at tyrosine 861. This product can also react with FAK (pTyr861) of mouse, chicken and human. Focal adhesion kinase (FAK) is a non-receptor cytoplasmic protein tyrosine kinase. It is coded by the PTK2 (protein tyrosine kinase 2) gene that is located on human chromosome 8q24.3. |
| Immunogen【免疫原】 | synthetic phosphopeptide derived from the region of FAK that contains tyrosine 861. |
| Application【应用】 | Anti-phospho-FAK (pTyr861) antibody can be used in western blotting (diluted 1:1000). |
| Biochem/physiol Actions【生化/生理作用】 | Focal adhesion kinase (FAK) participates in cell signaling pathways that leads to cell proliferation, invasion, survival and metastasis. It is essential for normal embryonic development. This protein controls CSC (cancer stem cells) properties in breast, gastrointestinal and squamous cell carcinoma. |
| Physical form【外形】 | Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 50% glycerol, 1.0 mg/ml BSA (IgG and protease free) and 0.05% sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous glycerol solution |
| species reactivity | mouse, human, chicken, frog |
| technique(s) | immunohistochemistry: suitable western blot: 1:1,000 |
| UniProt accession no.【UniProt登记号】 | Q05397 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... PTK2(5747) mouse ... Ptk2(14083) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
