Anti-phospho-HDAC9/HDAC4/HDAC5 (pSer²⁴⁶/pSer²⁵⁹/pSer²²⁰) antibody produced in rabbit

NA.41

Peptide sequence around phosphorylation site of serine 246/259/220 (T-A-S(p)-EP), according to the protein HDAC9/HDAC4/HDAC5.

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Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

~124 kDa
~140 kDa

human, mouse

1 mg/mL

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000

IgG

(T-A-SP-EP)

NP_001015053.1
NP_006028.2
NP_055522.1

P56524

wet ice

−20℃

human ... HDAC4(9759), HDAC5(10014), HDAC9(9734)

Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general,they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of HDACs; classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to substantial interest in HDAC inhibitors as possible antineoplastic agents.

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10 - Combustible liquids

WGK 1