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Anti-phospho-PGR (pSer190) antibody produced in rabbit
产品别名
Anti-phospho-PGR (pSer190) antibody produced in rabbit
Anti-PR antibody produced in rabbit
Anti-progesterone receptor antibody produced in rabbit
Anti-NR3C3 antibody produced in rabbit
基本信息
MDL number | MFCD00239723 |
NACRES | NA.41 |
Immunogen【免疫原】 | Peptide sequence around phosphorylation site of serine 190 (G-L-S(p)-P-A), according to the protein PGR. |
Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
Physical form【外形】 | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
产品性质
biological source【生物来源】 | rabbit |
conjugate【偶联物】 | unconjugated |
antibody form【抗体形式】 | affinity isolated antibody |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
form【形式】 | buffered aqueous solution |
mol wt【分子量】 | ~99 kDa |
species reactivity | human |
concentration【浓度】 | 1 mg/mL |
technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 indirect immunofluorescence: 1:100-1:200 western blot: 1:500-1:1000 |
isotype【同位素/亚型】 | IgG |
immunogen sequence【免疫原序列】 | (G-L-SP-P-A) |
NCBI accession no.【NCBI登记号】 | NP_000917.3 |
UniProt accession no.【UniProt登记号】 | P06401 |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... PGR(5241) |
产品说明
Target description【目标描述】 | Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid,glucocorticoid and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation. The major signaling pathway used by progesterone receptors is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-kappaB, AP-1 or STAT. Progesterone receptors are found in the female reproductive tract, mammary glands, brain and pituitary gland and receptor expression is induced by estrogen. Well established functions of progesterone receptors include ovulation, implantation, mammary gland development and maintenance of pregnancy. In addition,progesterone, signaling through the progesterone receptor, increases the ventilatory response of the respiratory centers to carbon dioxide and decreases arterial and alveolar PCO2 in the luteal phase of the menstrual cycle and during pregnancy. The human gene encoding the progesterone receptor has been localized to 11q22. |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 1 |