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Anti-phospho-PKD1/2/3/PKC mu (pSer738+Ser742) antibody produced in rabbit
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Protein kinase D1 (PRKD1) belongs to the protein kinase D family. It is a serine/threonine kinase which is expressed in mammary glands. The gene encoding this protein is localized on human chromosome 14q12. |
| Immunogen【免疫原】 | The antiserum was produced against synthesized peptide derived from human PKD1/2/3/PKC mu around the phosphorylation site of Ser738 and Ser742. Immunogen Range: 706-755 |
| Biochem/physiol Actions【生化/生理作用】 | Protein kinase D1 (PRKD1) has a role in insulin secretion in the islets of Langerhans. The protein is involved in various cellular processes like DNA synthesis, cell cycle progression, initiation of the nuclear factor κB pathway, vesicular trafficking and apoptosis. It conserves epithelial phenotype by inhibiting epithelial-to-mesenchymal transition. PRKD1 acts as an effector of diacylglycerol and protein kinase C. Protein kinase D2 (PRKD2) is a mediator of tumor cell-endothelial cell communication. PRKD2 influences CD8+ T cell-dependent immune responses. It facilitates cell migration and it is associated with the progression and maintenance of various malignancies. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen 101 kDa |
| species reactivity | human, mouse, rat |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | ELISA: 1:5000 immunohistochemistry: 1:50-1:100 western blot: 1:500-1:1000 |
| NCBI accession no.【NCBI登记号】 | O94806 Q15139 Q9BZL6 |
| UniProt accession no.【UniProt登记号】 | Q9BZL6 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... PRKD1(5587), PRKD2(25865), PRKD3(23683) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
