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抗 磷酸化 Smad2 (pSer 250 ) 兔抗
Anti-phospho-Smad2 (pSer250) antibody produced in rabbit
产品别名
抗 磷酸化 Smad2 (pSer 250 ) 兔抗
Anti-phospho-Smad2 (pSer250) antibody produced in rabbit
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | SMAD2 (SMAD family member 2) is also called as MADR2 (substrate of the TGFβ receptor). It is located on human chromosome 18q21. This gene belongs to the mothers against Dpp (MAD) related family of proteins. SMAD2 has two highly conserved amino and carboxyl-terminal domains (MH1 and MH2 domains) but has no known structural motifs. |
| Immunogen【免疫原】 | The antiserum was produced against synthesized peptide derived from human Smad2 around the phosphorylation site of Ser250. Immunogen Range: 216-265 |
| Application【应用】 | Anti-phospho-Smad2 (pSer250) antibody has been used in immunoblotting. |
| Biochem/physiol Actions【生化/生理作用】 | SMAD2 (SMAD family member 2) plays an important role in TGF-β(transforming growth factor β)/activin signaling pathways. Mutations in SMAD2 (SMAD family member 2) results in arterial aneurysms and dissections. Upregulation of Smad2 blocks the multiplication of gingival epithelial cells. Smad2 positively and negatively controls TGFβ-dependent transcription with the help of forkhead DNA-binding protein FAST2. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen 52 kDa |
| species reactivity | mouse, rat, human |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | ELISA: 1:10000 western blot: 1:500-1:1000 |
| NCBI accession no.【NCBI登记号】 | Q15796 |
| UniProt accession no.【UniProt登记号】 | Q15796 |
| application(s) | research pathology |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... SMAD2(4087) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
