Anti-PTEN antibody, Rabbit monoclonal

NA.41

Phosphatase and tensin homolog deleted on chromosome ten (PTEN), a lipid phosphatase protein, is localized in the cell nucleus. It has a protein tyrosine phosphatase domain. The PTEN gene is located on human chromosome 10q23.

Synthetic peptide derived from the C-terminus of human PTEN protein.

Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a tumor suppressor gene. It negatively regulates the phosphatidylinositol 3-kinase (PI3K) pathway. PTEN protein might control the growth of cells through its lipid phosphatase activity. The protein tyrosine phosphatase domain of PTEN is known to dephosphorylate serine, threonine, and tyrosine residues. It may also participate in immune modulation. Mutation in the PTEN gene is associated with rare bilateral choroidal ganglioneuroma. Germline mutations in the PTEN gene are observed in Cowden′s syndrome (CS), Lhermitte–Duclos disease (LDD), and Bannayan–Zonana syndrome (BZS).

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0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

rabbit

100

expressed in proprietary host

unconjugated

affinity isolated antibody

primary antibodies

SP218, monoclonal

human (tested)

frog, mouse, dog

flow cytometry: 1:200
immunoblotting: 1:400
immunohistochemistry: 1:200

IgG

P60484

wet ice

2-8℃

human ... PTEN(5728)

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12 - Non Combustible Liquids

WGK 2