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Anti-RAB25 (C-Terminal) antibody produced in rabbit

产品编号:3389992
规格:~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
包装规格:200 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3389992200 μL4330
产品别名

Anti-RAB25 (C-Terminal) antibody produced in rabbit

Anti-CATX-8

基本信息
NACRES
NA.41
General description【一般描述】
RAB25 (Ras-related protein 25) belongs to the Rab family. It is located on chromosome 1q22. It is also called as Rab11c (Ras-related protein Rab11C). It is present in polarized epithelial cells.
Application【应用】
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Anti-RAB25 (C-Terminal) antibody produced in rabbit has been used in:
  • immunoblotting
  • immunoprecipitation
  • immunofluorescence

Biochem/physiol Actions【生化/生理作用】
Rab (Ras related in brain) GTPases are central regulators of membrane trafficking between the different subcellular compartments of the eukaryotic cell. Through their effector proteins, Rab GTPases helps to modulate vesicle formation, actin- and tubulin-dependent vesicle movement and membrane fusion. Rab proteins contain conserved regions involved in guanine-nucleotide binding, and hypervariable COOH-terminal domains with a cysteine motif, implicated in subcellular targeting. Rab25 is associated with the apical recycling system of epithelial cells. Rab25 is associated with the progression and aggressiveness of ovarian and breast cancers.
In glioblastoma multiforme cells, downregulation of RAB25 (Ras-related protein 25) blocks the in vitro cytotoxicity and in vivo antitumor actions. Hence, it is known to play a major role in tumorigenesis. Upregulation of Rab25 induces the invasion and multiplication of hepatocellular carcinoma cell.
Physical form【外形】
Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
200
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
antigen ~25 kDa
species reactivity
human
concentration【浓度】
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 5-10 μg using lysates of A431 cells
indirect immunofluorescence: 2-5 μg/mL using human HeLa cells
western blot: 0.2-0.5 μg/mL using lysates of HEK-293T cells over expressing human Rab25
UniProt accession no.【UniProt登记号】
P57735
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... RAB25(57111)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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