Anti-Rab8 antibody produced in rabbit

MFCD01634074

NA.41

Rab proteins contain conserved regions involved in guanine-nucleotide binding and hypervariable COOH-terminal domains with a cysteine motif. Rab8 localizes to the trans-Golgi network (TGN), recycling endosomes, tubular structures in the cytosol, membrane protrusions and plasma membrane.

Anti-Rab8 antibody produced in rabbit has been used in immunoblotting and immunofluorescence staining.

Rab8 (Ras-related protein Rab-8A) controls polarized trafficking, that helps in the formation of protrusion, ciliogenesis or intestinal epithelial. It may involve in the malignant development of EC (endometrial cancer). In human, Rab8 also participates in the dengue virus infection. It controls the translocation of in muscle cells.
Activation of a Rab protein is coupled to its association with intracellular membranes, allowing it to recruit downstream effector proteins to the cytoplasmic surface of a subcellular compartment. Through their effector proteins, Rab guanosine triphosphate (GTPases) regulate vesicle formation, actin- and tubulin-dependent vesicle movement and membrane fusion. The guanine-nucleotide binding and hypervariable COOH-terminal domains are implicated in subcellular targeting. Each Rab shows a characteristic subcellular distribution. Therefore, antibodies to Rab proteins may serve as useful tools for studying subcellular localization and membrane organization.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

rabbit

200

unconjugated

IgG fraction of antiserum

primary antibodies

polyclonal

buffered aqueous solution

antigen ~24 kDa

human, rat, mouse

indirect immunofluorescence: 1:100-1:200 using mouse 3T3 and rat NRK cells
western blot: 1:250-1:500 using whole extract of human Jurkat cells

P61006

dry ice

−20℃

human ... RAB8A(4218)
mouse ... Rab8a(17274)
rat ... Rab8a(117103)

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12 - Non Combustible Liquids

WGK 2

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)