您的位置：首页 > 产品中心 > Anti-REST antibody produced in rabbit
Anti-REST antibody produced in rabbit
产品别名
Anti-REST antibody produced in rabbit
Anti-NRSF
Anti-XBR
Anti-REST
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | REST (RE1 silencing transcription factor) is a transcriptional repressor, which is also termed as NRSF (neuron-restrictive silencer factor).{26,29} It is abundantly present in the body. The gene is located on human chromosome 4q12 (5). The antibody detects endogenous level of total REST protein. |
| Immunogen【免疫原】 | Peptide sequence around aa. 873-877 (R-E-E-A-S), according to the protein NP_001180437.1 |
| Biochem/physiol Actions【生化/生理作用】 | REST (RE1 silencing transcription factor) plays a major role in hematopoietic and cardiac differentiation. Mutations in REST lead to hereditary gingival fibromatosis. It serves as a tumor suppressor in breast cancer. In human embryonic stem cells, suppression of REST/NRSF affects their survival, lineage differentiation and signaling. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~121 kDa |
| species reactivity | human |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | western blot: 1:500-1:1000 |
| isotype【同位素/亚型】 | IgG |
| immunogen sequence【免疫原序列】 | (R-E-E-A-S) |
| NCBI accession no.【NCBI登记号】 | NM_001193508.1 |
| UniProt accession no.【UniProt登记号】 | Q13127 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... REST(5978) |
产品说明
| Target description【目标描述】 | Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
