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Anti-Ring1A antibody produced in rabbit
产品别名
Anti-Ring1A antibody produced in rabbit
Anti-RING1
Anti-RNF1
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | The antibody detects endogenous level of total Ring1A protein. |
| Immunogen【免疫原】 | Peptide sequence around aa. 35-39 ( I-A-V-S-P), according to the protein NP_002922.2 |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~58 kDa |
| species reactivity | human, rat, mouse |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | western blot: 1:500-1:1000 |
| isotype【同位素/亚型】 | IgG |
| immunogen sequence【免疫原序列】 | (I-A-V-S-P) |
| NCBI accession no.【NCBI登记号】 | NM_002931.3 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... Ring1A(6015) |
产品说明
| Target description【目标描述】 | Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of ′Lys-119′ of histone H2A, thereby playing a central role in histone code and gene regulation. H2A ′Lys-119′ ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
