Anti-RNF146 antibody produced in rabbit

NA.41

Ring finger protein 146 (RNF146, Iduna) is a poly(ADP-ribose) polymer binding and PARsylation dependent E3 ubiquitin ligase which ubiquitinates proteins for degradation by proteosomes. RNF146 is neuroprotective due to its inhibition of Parthanatos via binding with Poly(ADP-ribose) (PAR). RNF146 regulates Wnt signaling via ubiquitylation of auto-PARsylated tankyrase.

Anti-RNF146 polyclonal antibody reacts with human and mouse ring finger protein 146 proteins.

Synthetic peptide directed towards the C terminal region of human RNF146

Anti-RNF146 polyclonal antibody is used to tag ring finger protein 146 for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles ring finger protein 146 in Wnt signaling and neuroprotection.

Synthetic peptide located within the following region: AVVAQHSLTQQRLLVSNANQTVPDRSDRSGTDRSVAGGGTVSVSVRSRRP

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

rabbit

100

unconjugated

IgG fraction of antiserum

primary antibodies

polyclonal

buffered aqueous solution

39 kDa

rat, human, mouse, horse

0.5 mg - 1 mg/mL

western blot: suitable

NP_112225

Q9NTX7-2

wet ice

−20℃

human ... RNF146(81847)

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12 - Non Combustible Liquids

WGK 3