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Anti-RUNX1 (N-terminal) antibody produced in rabbit
| 产品编号： | 3393181 |
| 规格： | ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-RUNX1 (N-terminal) antibody produced in rabbit
Anti-CBF-α2
Anti-Acute myeloid leukemia 1 protein, AML-1
Anti-Core-binding Factor α2 subunit
Anti-SL3/AKV core-binding factor αB subunit
Anti-Polyomavirus enhancer-binding protein 2αB subunit
Anti-SL3-3 enhancer factor 2αB subunit
Anti-Runt-related transcription factor 1
Anti-Oncogne AML-1
Anti-PEBP2-αB, PEA2-αB
基本信息
| MDL number | MFCD07370485 |
| NACRES | NA.41 |
| General description【一般描述】 | RUNX1 encodes a DNA-binding subunit. Runt-related transcription factor 1 (RUNX1) is a transcription factor that plays an important role in hematopoiesis, osteogenesis and neurogenesis. It is a member of Runt-related transcription factors (RUNXs). It was first identified as a component of Polyomavirus enhancer binding protein 2 (PEBP2) and Moloney murine leukemia virus enhancer core binding factor (CBF). Three isoforms of the protein have been identified: RUNX1a, RUNX1b and RUNX1c. Structurally, it consists of Runt domain at the N-terminal region. |
| Immunogen【免疫原】 | synthetic peptide corresponding to amino acids 42-52 of human RUNX1, conjugated to KLH. The corresponding sequence is identical in rat and mouse. |
| Application【应用】 | Anti-RUNX1 (N-terminal) antibody produced in rabbit is suitable for indirect immunofluorescence and western blot. |
| Biochem/physiol Actions【生化/生理作用】 | RUNX activity is regulated by extracellular signaling pathways resulting in post-translational modifications, such as phosphorylation, acetylation and ubiquitination. It is linked to acute leukemia. RUNX1 (Runt-related transcription factor 1) plays a vital role in tumour suppression and oncogenic activities. During hematopoiesis, it is involved in hematopoietic development, hematopoietic stem cell homeostasis, and various blood malignancies. It may have clinicopathological impact on the proliferation of human bone marrow cells used for transplantation therapy. |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~48 kDa |
| species reactivity | rat (predicted), mouse, human |
| concentration【浓度】 | ~1.0 mg/mL |
| technique(s) | indirect immunofluorescence: 2-5 μg/mL using paraformaldehyde-fixed HeLa cells western blot: 0.25-0.5 μg/mL using HeLa cell lysate |
| UniProt accession no.【UniProt登记号】 | Q01196 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... RUNX1(861) mouse ... Runx1(12394) rat ... Runx1(50662) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
