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Anti-SDF2L1 antibody produced in rabbit

产品编号:3393936
规格:Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
包装规格:25 μL,100 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
339393625 μL2430
3393936100 μL5840
产品别名

Anti-SDF2L1 antibody produced in rabbit

Anti-SDF2-like protein 1 antibody produced in rabbit

Anti-Stromal cell-derived factor 2-like protein 1 precursor antibody produced in rabbit

Anti-PWP1-interacting protein 8 antibody produced in rabbit

基本信息
Human Protein Atlas Number【人类蛋白质图谱编号】
HPA005638    Human Protein Atlas characterization data
General description【一般描述】
Stromal cell-derived factor 2-like 1 (SDF2L1) is a member of the Pmt/rt protein family and is coded by Sdf2l1, an ER stress-inducible gene. It has an endoplasmic reticulum (ER)-retention-like motif called HDEL, at the carboxy (C)-terminus.
Immunogen【免疫原】
Stromal cell-derived factor 2-like protein 1 precursor recombinant protein epitope signature tag (PrEST)
Application【应用】
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Anti-SDF2L1 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem/physiol Actions【生化/生理作用】
Stromal cell-derived factor 2-like 1 (SDF2L1) is a component of the endoplasmic reticulum (ER) chaperone complex, which interacts with α- and β-defensins. Analysis of the SDF2L1 domain for binding of representative α-, β-, and θ-defensins have shown that α- and β-defensins bind SDF2L1 similarly, but is different for the binding to pro-θ-defensins. Thus, it is a factor involved in processing and sorting of all three defensin subfamilies. SDF2L1 interacts with the ER chaperone GRP78/BiP, the ER-associated degradation (ERAD) machinery and with misfolded proinsulin and regulates substrate availability for the ERAD system. It increases the time for misfolded proteins to achieve a correctly folded conformation and thus acts as a buffer for substrate availability for ERAD in pancreatic β-cells.
Features and Benefits【特点和优势】
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.
Linkage【联系】
Corresponding Antigen APREST73376.
Physical form【外形】
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
Legal Information【法律信息】
Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
product line【产品线】
Prestige Antibodies® Powered by Atlas Antibodies
form【形式】
buffered aqueous glycerol solution
species reactivity
human
packaging【包装】
antibody small pack of 25 μL
technique(s)
immunohistochemistry: 1:200- 1:500
immunogen sequence【免疫原序列】
SVLKLLNTHHRVRLHSHDIKYGSGSGQQSVTGVEASDDANSYWRIRGGSEGGCPRGSPVRCGQAVRLTHVLTGKNLHTHHFPSPLSNNQEVSAFGEDGEGDDLDLWTVRCSGQHWEREAAVRFQHVGTSVFLSVTGEQYGSPIRGQHEVHGMPSANTHNTWKAMEGIFIKPSVEPSAGHD
UniProt accession no.【UniProt登记号】
Q9HCN8
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... SDF2L1(23753)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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