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Anti-Sirt7 兔抗
Anti-Sirt7 antibody produced in rabbit
| 产品编号： | 3395298 |
| 规格： | affinity isolated antibody, buffered aqueous solution |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Sirt7 兔抗
Anti-Sirt7 antibody produced in rabbit
Anti-SIR2L7
Anti-Sir2-related protein type 7
Anti-Sirtuin (silent mating type information regulation 2 homolog) 7
基本信息
| MDL number | MFCD07784768 |
| NACRES | NA.41 |
| General description【一般描述】 | Nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase (Sir2) is one of the silent information regulator genes in yeast. It belongs to a family of proteins, that is found in organisms ranging from bacteria to complex eukaryotes. Proteins of this family share a core domain showing 25-60% sequence identity. The mammalian Sir2 gene family is comprised of seven members which are designated as Sirt1-7. |
| Immunogen【免疫原】 | synthetic peptide corresponding to amino acids 35-51 of human Sirt7, conjugated to KLH via a C-terminal cysteine residue. The sequence is identical in mouse. |
| Application【应用】 | Anti-Sirt7 antibody produced in rabbit has been used in western blotting analysis and immunofluorescence detection. |
| Biochem/physiol Actions【生化/生理作用】 | Sirt7 (sirtuin 7) is extensively found in protein associated with active rRNA genes (rDNA), in the nucleolus. It interacts with RNA polymerase I (Pol I) and histones. Overexpression of Sirt7 increases Pol I-mediated transcription, whereas knockdown of Sirt7 or inhibition of its catalytic activity results in decreased association of Pol I with rDNA and reduces Pol I transcription. Depletion of Sirt7 stops cell proliferation and triggers apoptosis. High levels of Sirt7 expression are associated with breast cancer. |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~45 kDa |
| species reactivity | human, mouse (predicted) |
| technique(s) | immunoprecipitation (IP): 2-4 μg using extracts of HEK-293T cells expressing human Sirt7 indirect immunofluorescence: 2-4 μg/mL using human HEK-293T cells western blot: 1-2 μg/mL using whole extracts of HEK-293T cells expressing human Sirt7 |
| UniProt accession no.【UniProt登记号】 | Q9NRC8 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... SIRT7(51547) mouse ... Sirt7(209011) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
