Anti-SLC31A1 antibody produced in rabbit

HPA013810    Human Protein Atlas characterization data

The gene SLC31A1 (solute carrier family 31, member 1) is also referred to as CTR1 and is predominantly expressed in the liver and kidney. The gene is mapped to human chromosome 9q32. Though the protein is mainly localized to the plasma membrane, in human carcinoma cell lines it is observed to be distributed in cytoplasmic vesicular compartments.

High affinity copper uptake protein 1 recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

The gene SLC31A1 (solute carrier family 31, member 1) encodes a copper transporter that is localized to the cell membrane. It is involved in the uptake of dietary copper. Overexpression of this protein leads to copper accumulation in cells. The encoded protein is also involved in the cellular accumulation and toxicity of platinum-based anti-cancer drugs, such as cisplatin. During early embryogenesis, it is found to play a role in propagating the fibroblast growth factor (FGF) signal.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST72883.

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

Prestige Antibodies^® Powered by Atlas Antibodies

buffered aqueous glycerol solution

human

antibody small pack of 25 μL

immunohistochemistry: 1:200- 1:500

IARESLLRKSQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFPHLLQTV

O15431

wet ice

−20℃

human ... SLC31A1(1317)

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10 - Combustible liquids

WGK 1

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)