Anti-Spectrin antibody produced in rabbit

MFCD00164739

NA.41

Spectrin is the major cytoskeletal component in erythrocytes. It is composed of two types of polypeptides known as α and β with molecular weights of 240 and 220 kDa, respectively. The α- and β-chains form heterotetramers which are linked end-to-end via oligomeric actin and band 4.1 protein.
Spectrin is a multifunctional protein that has lipid-binding sites within CH (calponin-homology) tandem domains, a PH (pleckstrin homology) domain and triple helical segments. It is located on chromosome 1q23.1.

The antibody reacts specifically with the α and β chains of human erythrocyte spectrin.

spectrin from freshly prepared human erythrocyte ghosts.

Anti-Spectrin antibody has been used in western blotting immunofluorescence and immunostaining.

The spectrin-based membrane skeleton is essential to provide mechanical stability and membrane integrity. It is also responsible for protein organization, trafficking and resilience of erythrocytes.
Spectrins modulates the cell morphology and mechanical properties. Spectrins also participates in the cell cycle by controlling the upregulation of membrane receptors. α- and β spectrins are essential for the development of nervous system.

rabbit

200

unconjugated

whole antiserum

primary antibodies

polyclonal

15 mM sodium azide

human

western blot: 1:400

P02549

dry ice

−20℃

human ... SPTA1(6708), SPTB(6710), SPTBN1(6711), SPTBN2(6712), SPTBN4(57731), SPTBN5(51332)

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