Anti-SUMO1 antibody produced in rabbit

NA.41

The immunogen for anti-SUMO1 antibody: synthetic peptide derected towards the N terminal of human SUMO1

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. It is involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. It may also regulate a network of genes involved in palate development.

Synthetic peptide located within the following region: DQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYC

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

rabbit

100

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

11 kDa

rabbit, dog, rat, guinea pig, human, bovine, horse, mouse

0.5 mg - 1 mg/mL

western blot: suitable

NM_009460

P63166

wet ice

−20℃

human ... SUMO1(7341)
mouse ... Sumo1(22218)

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12 - Non Combustible Liquids

WGK 3