Anti-Tensin 1 (internal) antibody produced in rabbit

NA.41

Tensin 1, also known as TNS1, is a member of tensin protein family. Tensins are multi domain proteins containing homologous C1, protein phosphatases (PTPases), C2, Src homology 2 (SH2) domains and pTyr-binding (PTB) domains. Tensin 1 mRNA is widely expressed in mouse embryo and various human adult tissues and is localized to focal adhesions.

synthetic peptide corresponding to a sequence located in the internal region of human tensin1, conjugated to KLH. The corresponding sequence is identical in rat and mouse tensin1.

Anti-Tensin 1 (internal) antibody produced in rabbit has been used in immunoblotting.

Tensins play an important role in regulating cell shape and motility. Tensin 1 is involved in organizing the actin cytoskeleton and mediating signal transduction. TNS1 is implicated in myofibroblast differentiation. In addition, it also helps myofibroblasts to form nascent fibronectin and collagen matrix.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

rabbit

200

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

antigen 225 kDa (rat)
antigen ~150 kDa (human)

human, rat

recombinant expression
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~1.5 mg/mL

western blot: 1-2 μg/mL using HEK-293T cells overexpressing human tensin1.
western blot: 1.5-3 μg/mL using lysates of A10 cells

Q9HBL0

dry ice

−20℃

human ... TNS1(7145)
mouse ... Tns1(21961)
rat ... Tns1(301509)

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