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Anti-TNF Receptor I antibody produced in rabbit
产品别名
Anti-TNF Receptor I antibody produced in rabbit
P60
CD120a
TNF-RI
TBPI
p55
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen 50 kDa |
| species reactivity | mouse, human, rat |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | ELISA: 1:20000 immunohistochemistry: 1:50-1:100 |
| NCBI accession no.【NCBI登记号】 | P19438 |
| UniProt accession no.【UniProt登记号】 | P19438 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... TNFRSF1A(7132) |
基本信息
| General description【一般描述】 | Tumor necrosis factor receptor 1 (TNFR1) belongs to the TNFR superfamily and is ubiquitously expressed. It comprises an extracellular domain with a cysteine-rich motif, a transmembrane segment, and an intracellular domain with a “death domain” motif. The TNFR1 gene is mapped to human chromosome 12p13.31. |
| Immunogen【免疫原】 | The antiserum was produced against synthesized peptide derived from human TNF Receptor I. Immunogen Range: 381-430 |
| Application【应用】 | Anti-TNF Receptor I antibody produced in rabbit has been used in immunostaining at a dilution of 1:200. |
| Biochem/physiol Actions【生化/生理作用】 | Tumor necrosis factor receptor 1 (TNFR1) is crucial for TNF for eliciting proinflammatory functions. Through its dead domain motif, TNFR1 interacts with the TNF receptor-associated death domain protein (TRADD). TNFR1 regulates cytotoxic signaling pathways. Blockage of TNFR1 in mouse model harboring respiratory syncytial virus (RSV) infection results in enhanced bronchoconstriction. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
