Anti-TSG101 (N-terminal) antibody produced in rabbit

MFCD08705530

NA.41

Tumor susceptibility gene 101 protein (TSG101) is mapped to human chromosome 11p15.1. TSG101 has ubiquitin E2 variant domain.

synthetic peptide corresponding amino acids 2-20 located at the N-terminus of human TSG101, conjugated to KLH. This sequence is identical in rat and mouse TSG101.

Tumor susceptibility gene 101 protein (TSG101) is a component of endosomal sorting complex required for transport (ESCRT) machinery. TSG101 interacts with arrestin domain-containing protein 1 and mediates its budding through plasma membrane. It binds to ubiquitinylated proteins and conveys them for degradation by lysosomes. TSG101 is also essential for the budding human immunodeficiency virus (HIV) infected cells. TSG101 deficiency is associated with genome instability and is considered as a risk factor for tumor initiation.

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

rabbit

200

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

antigen 46 kDa

rat, human, mouse

~1 mg/mL

microarray: suitable
western blot: 1-2 μg/mL using cell lysates of rat fibroblast Rat-1, mouse fibroblast NIH3T3, and human A431 cells, and rat brain extract (S1 cytosolic fraction)

Q99816

dry ice

−20℃

human ... TSG101(7251)
mouse ... Tsg101(22088)
rat ... Tsg101(292925)

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WGK 3

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)