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Anti-YB-1 (C-terminal) antibody produced in rabbit
| 产品编号： | 3406143 |
| 规格： | ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-YB-1 (C-terminal) antibody produced in rabbit
Anti-BP-8
Anti-Y BOX binding protein
Anti-CSDB
Anti-CSDA2
Anti-MDR-NF1
Anti-DBPB
Anti-NSEP1
Anti-YBOX1
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Y-box-binding protein (YB-1) also known as nuclease-sensitive element-binding protein 1 (NSEP1) is a member of the Cold-Sock Domain (CSD) containing proteins. It is composed of three domains: the N-terminal which is thought to function as a trans-activation regulatory domain, a highly conserved nucleic acid binding domain (the CSD), and C-terminal domain, involved in protein-protein interactions. |
| Specificity【特异性】 | Anti-YB-1 (C-terminal) antibody is specific for YB-1 in rats, mice and humans. The immunizing peptide specifically inhibits the detection of the YB-1 band by immunoblotting. |
| Immunogen【免疫原】 | synthetic peptide corresponding to amino acids 307-324 of human YB-1, conjugated to KLH. The corresponding sequence is identical in rat and mouse YB-1 proteins. |
| Application【应用】 | Anti-YB-1 (C-terminal) antibody has been used in
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| Biochem/physiol Actions【生化/生理作用】 | Y-box-binding protein (YB-1) is shown to bind to the Y-box promoter element to regulate gene expression. It plays an important role in a wide variety of cellular functions such as transcriptional and translation regulation, DNA repair, drug resistance, and stress responses. |
| Physical form【外形】 | Solution in 0.01 M phophate buffered saline, pH 7.4, containing 15 mM sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~50 kDa |
| species reactivity | rat, mouse, human |
| concentration【浓度】 | ~1.0 mg/mL |
| technique(s) | immunoprecipitation (IP): 5-10 μg using HEK-293T cell lysates indirect immunofluorescence: 2-5 μg/mL using paraformaldehyde-fixed NIH-3T3 cells western blot: 0.5-1 μg/mL using PC12 cell lysates |
| UniProt accession no.【UniProt登记号】 | P67809 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... YBX1(4904) mouse ... Ybx1(22608) rat ... Ybx1(500538) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
