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Anti-ZIP14 antibody produced in rabbit
| 产品编号： | 3406948 |
| 规格： | affinity isolated antibody, buffered aqueous solution |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-ZIP14 antibody produced in rabbit
Anti-NET34
Anti-SLC39A14
Anti-LZT-Hs4
Anti-Solute carrier family 39 member A14
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Solute carrier family 39 member 14 or Zrt- and Irt-like protein 14 (ZIP14), a transmembrane metal ion transporter, is a member of the LIV-1 subfamily. It contains eight transmembrane domains (TMDs), a metalloprotease, and a histidine-rich motif. ZIP14 is majorly expressed in the pancreas, liver, and heart. The ZIP14 gene is mapped to human chromosome 8p21.3. |
| Immunogen【免疫原】 | ZIP14 antibody was raised against a 16 amino acid peptide near the center of human ZIP14. |
| Application【应用】 | Anti-ZIP14 antibody produced in rabbit has been used in immunoblotting. 1:2500 |
| Biochem/physiol Actions【生化/生理作用】 | Zrt- and Irt-like protein 14 (ZIP14) is a divalent metal transporter specific for zinc (Zn). However, some studies report, it also mediates the transport of manganese (Mn), iron (Fe), and cadmium (Cd). ZIP14 along with ZIP8 are prime Mn2+ importers of the brain′s capillary bed and in human brain microvascular endothelial cells (HBMVEC) in in vitro conditions. Mutations in the ZIP14 gene lead to manganese dyshomeostasis, which in turn results in manganese accumulation in childhood-onset parkinsonism–dystonia patients. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Linkage【联系】 | The action of this antibody can be blocked using blocking peptide SBP3500603. |
| Physical form【外形】 | Supplied in PBS with 0.02% sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | predicted mol wt 54 kDa |
| species reactivity | human, mouse, rat |
| technique(s) | ELISA: suitable immunofluorescence: suitable immunohistochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_001128625 |
| UniProt accession no.【UniProt登记号】 | Q15043 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... SLC39A14(23516) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
