广州伟伯科技有限公司
您的位置:首页 > 产品中心 > 194874-06-1, Apoptolidin A Ready Made Solution
产品搜索:

Apoptolidin A Ready Made Solution

产品编号:3408978
规格:1 mg/mL in DMSO
CAS NO:194874-06-1
包装规格:500 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3408978500 μL9170
产品别名

194874-06-1

Apoptolidin A Ready Made Solution

FU 40A

Apoptolidin

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C58H96O21
Molecular weight
1129.37
EC number【EC 号】
200-664-3
PubChem Substance ID【PubChem化学物质编号】
329825615
General description【一般描述】
Chemical structure: macrolide
Biochem/physiol Actions【生化/生理作用】
Apoptolidin A is a 20-membered macrolide shown to be selectively cytotoxic against several cancer cell lines and noncytotoxic against normal cells. The molecule was originally produced by Nocardiopsis species, and its target site was identified as mitochondrial F0F1-ATPase.
Apoptolidin induces apoptosis selectively in rat glia cells transformed with the adenovirus oncogene E1A. Several minor apoptolidin congeners were isolated, known as Apoptolidins A-D. All apoptolidins were reported to inhibit growth of H292 cancer cells (lung carcinoma) in the submicromolar range. Recently, a stereo-selective synthesis of the Apoptolidin disaccharide was reported.
产品性质
Quality Level【质量水平】
200
biological source【生物来源】
Amycolatopsis sp.
form【形式】
DMSO solution
concentration【浓度】
1 mg/mL in DMSO
Mode of action【作用机制】
enzyme | inhibits
antibiotic activity spectrum【抗生素抗菌谱】
fungi
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
SMILES string
CC(/C=C1\C)=C\C(C)=C\[C@@H](C)[C@H](O[C@H]2[C@@H](O)[C@H](O)[C@@H](OC)[C@H](C)O2)/C=C/C(C)=C/CC[C@H](O)[C@@H](OC)CC([C@H]([C@]3([C@H](C)[C@@H](O)[C@@H](C)C(C[C@H](COC)O[C@H]4C[C@@](O)(C)[C@@H](O[C@H]5C[C@@H](OC)[C@H](O)[C@H](C)O5)[C@H](C)O4)O3)O)O)OC1=O
InChI
1S/C58H96O21/c1-29-17-16-18-40(59)43(69-13)25-45(76-55(65)33(5)23-31(3)21-30(2)22-32(4)41(20-19-29)77-56-51(63)50(62)52(71-15)37(9)74-56)53(64)58(67)35(7)48(60)34(6)42(79-58)24-39(28-68-12)75-47-27-57(11,66)54(38(10)73-47)78-46-26-44(70-14)49(61)36(8)72-46/h17,19-23,32,34-54,56,59-64,66-67H,16,18,24-28H2,1-15H3/b20-19+,29-17+,30-22+,31-21+,33-23+/t32-,34+,35-,36+,37+,38+,39-,40+,41-,42?,43+,44-,45?,46+,47+,48+,49-,50+,51+,52+,53-,54+,56+,57+,58-/m1/s1
InChI key
WILMROCKORZEMQ-XIQAQMKHSA-N
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)【闪点(F)】
188.6 °F
Flash Point(C)【闪点(C)】
87 ℃
广州伟伯科技有限公司 版权所有 CopyRight ©2006-2024, All Rights Reserved
工信部备案号:粤ICP备08114744号   Page Run Time: 0.0137