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Aprindine 盐酸盐
Aprindine hydrochloride
| 产品编号： | 3408998 |
| 规格： | ≥98% (HPLC), solid |
| CAS NO： | 33237-74-0 |
| 包装规格： | 10 MG，50 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
33237-74-0
Aprindine 盐酸盐
Aprindine hydrochloride
N-(2,3-Dihydro-1H-inden-2-yl)-N′,N′-diethyl-N-phenyl-1,3-propanediamine hydrochloride
Amidonal
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C22H30N2 · HCl |
| Molecular weight | 358.95 |
| EC number【EC 号】 | 251-418-7 |
| MDL number | MFCD01698392 |
| PubChem Substance ID【PubChem化学物质编号】 | 329770937 |
| NACRES | NA.77 |
| Application【应用】 | Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine hydrochloride also inhibits the activities of calmodulin-sitmulated cyclic 3′:5′-nucleotide phosphodiesterase and Ca-ATPase. |
| Biochem/physiol Actions【生化/生理作用】 | Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine shows structure similarities to lidocaine and procainamide and is effective in treatment of patients with ventricular premature depolarizations, ventricular tachycardia, and supraventricular arrhythmias. Aprindine inhibits the activation of bovine brain cyclic 3′:5′-nucleotide phosphodiesterase (EC 3.1.4.17) by calmodulin and inhibits calmodulin-stimulated Ca-ATPase (ATP phosphohydrolase EC 3.6.1.3) activity. |
| Features and Benefits【特点和优势】 | This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| solubility【溶解性】 | H2O: >10 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Cl.CCN(CC)CCCN(C1Cc2ccccc2C1)c3ccccc3 |
| InChI | 1S/C22H30N2.ClH/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22;/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3;1H |
| InChI key | KIPFVRHNAAZJOD-UHFFFAOYSA-N |
| packaging【包装】 | 10, 50 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 - H315 - H319 - H335 |
| Precautionary Statements | P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |
