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ARC 239 二盐酸盐 水合物
ARC 239 dihydrochloride hydrate
产品别名
67339-62-2
ARC 239 二盐酸盐 水合物
ARC 239 dihydrochloride hydrate
(2-[2-[4-(o-Methoxyphenyl)piperazin-1-yl]ethyl]-4,4-dimethyl-1,3-(2H,4H)-isoquinolinedione dihydrochloride hydrate
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C24H29N3O3·2HCl · xH2O |
| Molecular weight | 480.43 (anhydrous basis) |
| MDL number | MFCD16875414 |
| PubChem Substance ID【PubChem化学物质编号】 | 329770834 |
| Application【应用】 | ARC 239 is a potent α-adrenoceptor blocking drug, competitively antagonizing pressor responses to adrenaline and inhibiting pressor responses to noradrenaline, phenylephrine, tyramine, and dimethylphenylpiperazinium. |
| Biochem/physiol Actions【生化/生理作用】 | ARC 239 is a selective α-2B adrenergic blocker. Although ARC-239, like prazosin, also has some alpha-1 antagonist activity, it is used most commomly to differentiate alpha-2A/D from alpha-2B and alpha-2C subtypes rather than for any alpha-1 inhibition.. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | H2O: >5 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O.Cl.Cl.COc1ccccc1N2CCN(CC2)CCN3C(=O)c4ccccc4C(C)(C)C3=O |
| InChI | 1S/C24H29N3O3.2ClH.H2O/c1-24(2)19-9-5-4-8-18(19)22(28)27(23(24)29)17-14-25-12-15-26(16-13-25)20-10-6-7-11-21(20)30-3;;;/h4-11H,12-17H2,1-3H3;2*1H;1H2 |
| InChI key | KWVGFMWBNZTADI-UHFFFAOYSA-N |
| packaging【包装】 | 5 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07,GHS09 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 - H400 |
| Precautionary Statements | P273 - P301 + P312 + P330 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Aquatic Acute 1 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
