BD 1063 dihydrochloride

C₁₃H₁₈Cl₂N₂ · 2HCl

346.12

MFCD00792740

329825284

NA.77

BD 1063 dihydrochloride has been used as a sigma-1 receptor (S1R) antagonist:

• to study the in vitro and in vivo protective action of S1R against ferroptosis in hepatocellular carcinoma cells
• in a comparative evaluation of its anti-hyperalgesic action with that of the effects of N-(2-morpholin-4-yl-ethyl)-2-(1-naphthyloxy) acetamide (NMIN) in a chronic constriction injury model (CCI)
• to study the contribution of sigma receptors inhibition to the neuroprotective effects of memantine against amyloid-beta (Aβ)-induced neurotoxicity in SH-SY5Y cells

BD 1063 is a potent sigma(1) receptor antagonist; approximately 50-fold selective for sigma-1 over sigma-2 and 100-fold or more selective over 9 other tested neurotransmitter receptors. BD 1063 has been shown to antagonize cocaine efffects.

air sensitive

100

≥98% (HPLC)

powder

desiccated

white to beige

H₂O: >15 mg/mL

room temp

Cl.Cl.CN1CCN(CC1)CCc2ccc(Cl)c(Cl)c2

1S/C13H18Cl2N2.2ClH/c1-16-6-8-17(9-7-16)5-4-11-2-3-12(14)13(15)10-11;;/h2-3,10H,4-9H2,1H3;2*1H

NXFDBTLQOARIMH-UHFFFAOYSA-N

5, 25 mg in glass bottle

GHS07

Warning

H319

P305 + P351 + P338

Eye Irrit. 2

13 - Non Combustible Solids

WGK 3