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BF-170 hydrochloride
| 产品编号： | 3413982 |
| 规格： | ≥98% (HPLC), solid |
| CAS NO： | 22191-97-5 |
| 包装规格： | 5 MG，25 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
22191-97-5
BF-170 hydrochloride
NSC 168387 hydrochloride
2-(4-aminophenyl)quinoline hydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C15H12N2 · HCl |
| Molecular weight | 256.73 |
| MDL number | MFCD08705340 |
| PubChem Substance ID【PubChem化学物质编号】 | 24891766 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | BF-170 is a new probe for neurofibrillary tangles (tau fibrils). It exhibits greater binding affinity to tau than to Aβ fibrils, EC50 = 221 nM vs. EC50 = 786 nM (Ki for Aβ > 5,000 nM). BF-170 demonstrates fast clearance from the brain; clearly visualizes neurofibrillary tangles, neuropil threads, and paired helical filament-type neuritis. BF-70 may become one of the candidate compounds for in vivo imaging of tau pathology associated with Alzheimer′s disease and is a useful tool in distinguishing among tau and Aβ fibrils specifically in AD. |
| Caution【注意】 | Product is air sensitive, store under inert gas. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| storage condition【储存条件】 | desiccated protect from light under inert gas |
| color【颜色】 | orange |
| solubility【溶解性】 | H2O: 10 mg/mL |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | Cl[H].Nc1ccc(cc1)-c2ccc3ccccc3n2 |
| InChI | 1S/C15H12N2.ClH/c16-13-8-5-12(6-9-13)15-10-7-11-3-1-2-4-14(11)17-15;/h1-10H,16H2;1H |
| InChI key | UYYPMQOFLJHJAW-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS05,GHS07 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H302 - H315 - H318 - H335 |
| Precautionary Statements | P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
