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比卡鲁胺
Bicalutamide
| 产品编号： | 3414031 |
| 规格： | European Pharmacopoeia (EP) Reference Standard |
| CAS NO： | 90357-06-5 |
| 包装规格： |
| 产品类别： | 进口试剂 |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3414031 | 1400 |
产品别名
90357-06-5
比卡鲁胺
Bicalutamide
Cosudex
Casodex
Bicalutamide (CDX)
N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
比卡胺
比卡他胺
N-[4-氰基-3-(三氟甲基)苯基]-3-(4-氟苯硫酰基)-2-甲基-2-羟基丙酰胺
比卡鲁胺 (CDX)
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H14F4N2O4S |
| Molecular weight | 430.37 |
| MDL number | MFCD00869971 |
| PubChem Substance ID【PubChem化学物质编号】 | 329831426 |
| NACRES | NA.24 |
| General description【一般描述】 | This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia. |
| Biochem/physiol Actions【生化/生理作用】 | 比卡鲁胺 (CDX) 是一种非杀菌的雄激素受体 (AR) 拮抗剂，是纯抗雄激素。它通过平衡组蛋白乙酰化/去乙酰化和共调剂募集发挥作用。比卡鲁胺(CDX)消除了雄激素介导的表达。例如，前列腺癌、PLZF(早幼粒细胞白血病锌指蛋白)和GADD45γ中的MMP13上调(生长停滞和可诱导的DNA损伤，γ)。通过雄激素，对PI3K /AKT磷酸化进行非基因组、非转录依赖性刺激，抑制比卡鲁胺(CDX)。 |
| Caution【注意】 | Please find SDS provided by EDQM here.. |
| Other Notes【其他说明】 | Sales restrictions may apply. |
产品性质
| grade【等级】 | pharmaceutical primary standard |
| manufacturer/tradename | EDQM |
| application(s) | pharmaceutical (small molecule) |
| format【格式】 | neat |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc2ccc(C#N)c(c2)C(F)(F)F |
| InChI | 1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25) |
| InChI key | LKJPYSCBVHEWIU-UHFFFAOYSA-N |
| Gene Information | human ... AR(367) |
| packaging【包装】 | Unit quantity: 160 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue. |
安全信息
| Pictograms【象形图】 | GHS08,GHS09 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H351 - H360FD - H410 |
| Precautionary Statements | P202 - P273 - P280 - P308 + P313 - P391 - P405 |
| Hazard Classifications【危险分类】 | Aquatic Chronic 1 - Carc. 2 - Repr. 1B |
| Storage Class Code【储存分类代码】 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
