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BIO-Acetoxime
产品别名
667463-85-6
BIO-Acetoxime
BIA
6-Bromoindirubin acetoxime
(3Z)-3-[(3E)-3-[(Acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-2H-Indol-2-one
6-Bromoindirubin-3′-acetoxime
(2′Z,3′E)-6-Bromoindirubin-3′-acetoxime
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H12BrN3O3 |
| Molecular weight | 398.21 |
| MDL number | MFCD09037533 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825535 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor that reduces invasiveness of gliomas and extends animal survival in intracranial glioma models. Also, BIO-Acetoxime induces Wnt signaling and inhibits CD8+ T cell effector differentiation. |
| Features and Benefits【特点和优势】 | This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | , dark red to purple |
| solubility【溶解性】 | H2O: 2 mg/mL (clear solution, warmed) |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CC(=O)O\N=C1\C(Nc2ccccc12)=C3\C(=O)Nc4cc(Br)ccc34 |
| InChI | 1S/C18H12BrN3O3/c1-9(23)25-22-16-12-4-2-3-5-13(12)20-17(16)15-11-7-6-10(19)8-14(11)21-18(15)24/h2-8,20H,1H3,(H,21,24)/b17-15-,22-16+ |
| InChI key | MENDIXKFTXYTHJ-HPBPSMLHSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07,GHS09 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 - H410 |
| Precautionary Statements | P273 - P301 + P312 + P330 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
